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CTGF / CCN2 Recombinant Protein

CAT: 0223-11-433Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-11-433Size:0.1 mg
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Background
Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CCN1-6) family of modular matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Analysis of CCN2 function in vivo has focused primarily on its key role as a mediator of excess ECM synthesis in multiple fibrotic diseases.
CAS Number
9000-83-3
NCBI Gene ID
14219
Swiss Prot
P29268
Accession Number
NP_034347.2
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>90% as determined by SDS-PAGE.
Buffer
Tris with Potassium glutamate and Arginine, pH7.0
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
37.3 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 37.3 kDa. The protein migrates as 37-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
Cellular communication network factor 2
NCBI Organism
Mus musculus
Background Reference 01
Faith Hall-Glenn., et al. 2011, Cell Mol Life Sci., 68 (19), 3209–3217.
Background Reference 02
Nakanishi T., et al. 2000, Endocrinology., 141 (1), 264-73.
Background Reference 03
Ball DK., et al. 2000, J Endocrinol., 176 (2), R1-7.
Other Product Names
CCN2, NOV2, HCS24, IGFBP8, IBP-8, IGFBP-8, IGF-binding protein 8
Tested Applications
ELISA, WB
Species
Mouse
Physical Properties
Lyophilized

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