CD80 Recombinant Protein

• Background :

  CD80 (B7-1) and CD86 (B7-2) together with their receptors CD28 and CTLA-4 constitute one of the dominant costimulatory pathways that regulate T cell and B cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells and germinal center B cells. Additionally, B7-2 is expressed at low levels on monocytes and can be up-regulated through interferon-gamma. B7-1 and B7-2 are both members of the immunoglobulin superfamily. It has been observed that both human and mouse B7-1 and B7-2 can bind to either human or mouse CD28 and CTLA-4, suggesting that there are conserved amino acids which form the B7-1/B7-2/CD28/CTLA-4 critical binding sites.

• NCBI Gene ID :

  12519

• Swiss Prot :

  Q15116

• Accession Number :

  NP_033985

• Tag :

  Fc Tag

• Type :

  Recombinant Proteins

• Source :

  CHO cells

• Field of Research :

  Immunology, Innate Immunity

• Buffer :

  Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 μ g/ml in sterile PBS.

• Shipping Conditions :

  Room Temp

• Storage Conditions :

  Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.

• Applications Notes :

  This recombinant proteins is for research use only.

• NCBI Official Name :

  CD80 antigen

• NCBI Organism :

  Mus musculus

• Other Product Names :

  B7-1

• Species :

  Mouse

• Protein ID :

  112983684

• Physical Properties :

  Lyophilized

• CAS Number :

  9000-83-3