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CD40 Recombinant Protein

CAT: 0223-96-983Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0223-96-983Size:0.1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD40 is also known as TNFRSF5, Bp50, CDW40, MGC9013, TNFRSF5 and p50, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins, and plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. CD40 contains 4 cysteine-rich repeats in the extracellular domain, and is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. The extracellular domain has the cysteinerich repeat regions, which are characteristic for many of the receptors of the TNF superfamily. Interaction of CD40 with its ligand, CD40L, leads to aggregation of CD40 molecules, which in turn interact with cytoplasmic components to initiate signaling pathways. Early studies on the CD40-CD40L system revealed its role in humoral immunity. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3), an autosomal recessive disorder characterized by an inability of B cells to undergo isotype switching, as well as an inability to mount an antibody-specific immune response, and a lack of germinal center formation.
CAS Number
9000-83-3
NCBI Gene ID
21939
Swiss Prot
P27512-1
Accession Number
P27512
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
44.9 kDa
Applications Notes
This recombinant protein can be used for E, WB. For research use only.
NCBI Official Name
Tumor necrosis factor receptor superfamily member 5
NCBI Organism
Mus musculus
Background Reference 01
Banchereau, J. et al., 1994, Annu. Rev. Immunol. 12: 881-922.
Background Reference 02
Ni, C.Z. et al., 2000, Proc. Natl. Acad. Sci. U.S.A. 97: 10395-10399.
Background Reference 03
Ferrari.S. et al., 2001, Proc. Natl. Acad. Sci. U.S.A. 98: 12614-12619.
Background Reference 04
Bhushan, A and Covey, L.R. 2001, Immunol. Res. 24: 311-324.
Other Product Names
CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50
Tested Applications
ELISA, WB
Species
Mouse
Physical Properties
Lyophilized

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