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DC-SIGN Antibody / CD209

CAT: 0800-V3452-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V3452-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DC-SIGN / CD209 is a transmembrane receptor that is expressed on the surface of dendritic cells and macrophages. It is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization, which allows the receptor to bind multivalent ligands with high avidity.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 0.5-1 µg/mL for 30 min at RT
UniProt
Q9NNX6
Host
Mouse
Reactivity
Human
Immunogen
A human partial recombinant protein was used as the immunogen for the DC-SIGN antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
C209/1781
Applications
WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the DC-SIGN antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This DC-SIGN antibody is available for research use only.
Storage Conditions
Store the DC-SIGN antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Titering of the DC-SIGN antibody may be required for optimal performance.
Location
Cytoplasmic, membranous, secreted
Image Legend
IHC testing of FFPE human lung carcinoma with DC-SIGN antibody (clone C209/1781) . Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9, for 10-20.

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