CD38 Recombinant Protein

• Background:

  CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.

• NCBI Gene ID:

  12494

• Swiss Prot:

  P56528

• Accession Number:

  NP_031672.2

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Homeostasis, Immunology, Obesity, Signal Transduction, Stem Cell

• Purity:

  >90% as determined by SDS-PAGE.

• Buffer:

  50 mM MES, 100 mM NaCl, pH6.5

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  31.7 kDa

• Applications Notes:

  This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 31.7 kDa. The protein migrates as 38-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

• NCBI Official Name:

  CD38 antigen

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Orciani M., et al., 2008, J. Cell. Biochem. 105 (3) : 905–12.

• Background Reference 02:

  Nata K., et al., 1997, Gene 186 (2) : 285–92.

• Background Reference 03:

  Malavasi F., et al., 2008, Physiol. Rev. 88 (3) : 841–86.

• Other Product Names:

  CD38, T10, cADPr hydrolase 1

• Tested Applications:

  WB

• Species:

  Mouse

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3