CD38 Antibody [90]

• Background:

  Murine CD38, a type II transmembrane glycoprotein, is a bifunctional ectoenzyme capable of catabolizing nicotinamide adenine dinucleotide (NAD+) to cyclic ADP-ribose (cADPR), and then hydrolyzing cADPR to adenosine diphosphoribose (ADPR) . It is expressed at high levels on the surface of peripheral B-lineage cells and at low density on germinal center B cells from unimmunized mice. It has also been reported to be expressed at moderate levels on NK cells, a proportion of peripheral T cells, and a subpopulation of thymocytes which are mostly TCRalphabeta+, CD4-, CD8-. Murine CD38 is also expressed by all Mac-1+ macrophages in the peritoneal cavities of unimmunized mice but not by unstimulated bone-marrow-derived macrophages. Monoclonal antibodies to CD38 have been shown to induce B and T cell proliferation, protect B cells from apoptosis, and inhibit B lymphopoiesis.

• NCBI Gene ID:

  12494

• Swiss Prot:

  P56528

• Accession Number:

  P56528

• Host:

  Rat

• Reactivity:

  Mouse

• Immunogen:

  Mouse bone marrow pre-B cells

• Clonality:

  Monoclonal

• Clone:

  [90]

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Immunology, Obesity, Signal Transduction

• Concentration:

  0.5 mg/mL

• Buffer:

  Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store vial at 2-8˚ C

• Fragment:

  IgG2a

• Specificity:

  CD38

• Applications Notes:

  CD38 Antibody [90] for use in flow cytometry, immunohistochemistry, immunoprecipitation, and stimulation assays.

• Symbol:

  Cd38

• NCBI Official Name:

  CD38 antigen

• NCBI Organism:

  Mus musculus

• Other Product Names:

  T10, ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase

• Tested Applications:

  WB, IHC-Fr, ICC, Flow

• Physical Properties:

  Liquid