Carboxypeptidase B2 Recombinant Protein

• Background:

  Carboxypeptidase B2 (CPB2) is a secreted enzyme that belongs to the peptidase M14 family. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen by the liver and circulates in the plasma as a plasminogen-bound zymogen. CPB2 cleaves C-terminal arginine or lysine residues from biologically active peptides, such as kinins or anaphylatoxins, in the circulation regulating their activities. CPB2 also down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. CPB2 exhibits carboxypeptidase activity when it is activated by proteolysis at residue Arg92 of the thrombin/thrombomodulin complex. Activated CPB2 reduces fibrinolysis by removing the fibrin C-terminal residues that are important for the binding and activation of plasminogen.

• NCBI Gene ID:

  1361

• Swiss Prot:

  Q96IY4

• Accession Number:

  Q96IY4

• Tag:

  C-6 His tag

• Type:

  Recombinant Proteins

• Source:

  Human Cells

• Field of Research:

  Signal Transduction

• Buffer:

  Supplied as a 0.2 um filtered solution of 20mM TrisHCl,150mM NaCl,1mM ZnCl2,10%Glycerol, pH7.5. It is not recommended to reconstitute to a concentration less than 100 ug/ml.

• Shipping Conditions:

  Dry Ice

• Calculated Molecular Weight:

  47 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Carboxypeptidase B2

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Carboxypeptidase B2, Carboxypeptidase U, CPU, Plasma Carboxypeptidase B, pCPB, Thrombin-Activable Fibrinolysis Inhibitor, TAFI, CPB2

• Species:

  Human

• Protein ID:

  530363504

• Physical Properties:

  Liquid

• CAS Number:

  9000-83-3