CD80 Recombinant Protein

CAT: 0223-96-044Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0223-96-044Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
B7-1 and B7-2, together with their receptors CD28 and CTLA­4, constitute one of the dominant co-stimulatory pathways that regulate T­ and B­cell responses. Although both CTLA­4 and CD28 can bind to the same ligands, CTLA­4 binds to B7­1 and B7­2 with a 20 ­ 100 fold higher affinity than CD28 and is involved in the down­regulation of the immune response. B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation) . CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-κB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
CAS Number
9000-83-3
NCBI Gene ID
941
Swiss Prot
P33681
Accession Number
P33681-1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Cell Cycle, Chemokines & Cytokines, Immunology, Innate Immunity, Signal Transduction
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
25.8 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
CD80 molecule
NCBI Organism
Homo sapiens
Background Reference 01
Peach RJ., et al., 1995, J. Biol. Chem. (UNITED STATES) 270 (36) : 21181–7.
Background Reference 02
Stamper CC., et al., 2001, Nature (England) 410 (6828) : 608–11.
Background Reference 03
Bhatia S., et al., 2005, Proc. Natl. Acad. Sci. 102: 15569-15574.
Background Reference 04
Khan N., et al., 2007, Int. Immunol. 19:477-486.
Other Product Names
CD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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