CD80 Recombinant Protein

• Background:

  B7-1 and B7-2, together with their receptors CD28 and CTLA­4, constitute one of the dominant co-stimulatory pathways that regulate T­ and B­cell responses. Although both CTLA­4 and CD28 can bind to the same ligands, CTLA­4 binds to B7­1 and B7­2 with a 20 ­ 100 fold higher affinity than CD28 and is involved in the down­regulation of the immune response. B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation) . CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-κB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.

• NCBI Gene ID:

  941

• Swiss Prot:

  P33681

• Accession Number:

  P33681-1

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Cancer, Cell Cycle, Chemokines & Cytokines, Immunology, Innate Immunity, Signal Transduction

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  25.8 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  CD80 molecule

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Peach RJ., et al., 1995, J. Biol. Chem. (UNITED STATES) 270 (36) : 21181–7.

• Background Reference 02:

  Stamper CC., et al., 2001, Nature (England) 410 (6828) : 608–11.

• Background Reference 03:

  Bhatia S., et al., 2005, Proc. Natl. Acad. Sci. 102: 15569-15574.

• Background Reference 04:

  Khan N., et al., 2007, Int. Immunol. 19:477-486.

• Other Product Names:

  CD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3