ANGPTL7 / CDT6 Recombinant Protein

• Background:

  Angiopoietin-like 7 (ANGPTL7) is also known as Corneal-Derived Transcript 6 (CDT6), and is a secreted glycoprotein that is structurally related to the angiopoietins. It is expressed in the corneal stroma, trabecular meshwork, and sclera and is elevated in glaucoma aqueous humor. Recently, ANGPTL proteins, including ANGPTL-2, -3, -4, -5 and -7, are identified as growth factors in combination with SCF, Thrombopoietin, IGF-II and FGF acidic that enhance the expansion and engraftment of human and mouse hematopoietic stem cells.

• NCBI Gene ID:

  10218

• Swiss Prot:

  O43827

• Accession Number:

  NP_066969.1

• Tag:

  Mouse IgG Fc Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Other

• Purity:

  >90% as determined by SDS-PAGE.

• Buffer:

  Tris with Glycine, Arginine and NaCl, pH7.5

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  64.1 kDa

• Applications Notes:

  This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 64.1 kDa. The protein migrates as 60 kDa and 76 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

• NCBI Official Name:

  Angiopoietin like 7

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Peek R., et al., 1998, Invest. Opthalmol. Visual Sci. 39 (10) : 1782-1788.

• Background Reference 02:

  Peek R., et al., 2002, J. Biol. Chem. 277 (1) : 686-693.

• Background Reference 03:

  Kuchtey, J. et al., 2008, Invest. Opthalmol. Visual Sci. 49 (8) : 3438-3448.

• Other Product Names:

  ANGPTL7, CDT6

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3