Itaconic acid (Standard)

CAT: 0804-HY-Y0520R-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0804-HY-Y0520R-01Size:10 mg
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AVAILABILITY: InStock
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Description
Itaconic acid (Standard) is the analytical standard of Itaconic acid. This product is intended for research and analytical applications. Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. Itaconic acid has anti-inflammatory, anti-microbial and immunomodulatory effect[1][2][4][5].
CAS Number
[97-65-4]
Product Name Alternative
Methylenesuccinic acid (Standard)
UNSPSC
12352211
Hazard Statement
H315, H318, H335
Target
Endogenous Metabolite; Ferroptosis; Reference Standards
Type
Reference Standards
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/itaconic-acid-standard.html
Purity
99.99
Smiles
O=C(O)C(CC(O)=O)=C
Molecular Formula
C5H6O4
Molecular Weight
130.10
Precautions
H315, H318, H335
References & Citations
[1]Weiss JM, et, al. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. J Clin Invest. 2018 Aug 31;128 (9) :3794-3805.|[2]Zhao M, et, al. Itaconic acid production in microorganisms. Biotechnol Lett. 2018 Mar;40 (3) :455-464.|[3]Qu C, et al. Itaconic acid induces ferroptosis by activating ferritinophagy. Biochem Biophys Res Commun. 2021 Oct 25;583:56-62. |[4]Zhu X, et al. Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS. Sci Rep. 2021 Sep 13;11 (1) :18173.|[5]Umbrasas D, et al. Effects of itaconic acid on neuronal viability and brain mitochondrial functions. J Bioenerg Biomembr. 2021 Oct;53 (5) :499-511.
Shipping Conditions
Room Temperature
Storage Conditions
4°C, sealed and dry storage, away from light and moisture
Scientific Category
Reference Standards
Clinical Information
No Development Reported

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