Itaconic acid

• UNSPSC Description:

  Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. Itaconic acid has anti-inflammatory, anti-microbial and immunomodulatory effect[1][2][4][5].

• Target Antigen:

  Endogenous Metabolite; Ferroptosis

• Type:

  Natural Products

• Related Pathways:

  Apoptosis;Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Inflammation/Immunology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/propylenedicarboxylic-acid.html

• Purity:

  99.98

• Solubility:

  H2O : 27.78 mg/mL (ultrasonic)

• Smiles:

  O=C(O)C(CC(O)=O)=C

• Molecular Weight:

  130.10

• References & Citations:

  [1]Weiss JM, et, al. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. J Clin Invest. 2018 Aug 31;128(9):3794-3805.|[2]Zhao M, et, al. Itaconic acid production in microorganisms. Biotechnol Lett. 2018 Mar;40(3):455-464.|[3]Qu C, et al. Itaconic acid induces ferroptosis by activating ferritinophagy. Biochem Biophys Res Commun. 2021 Oct 25;583:56-62. |[4]Zhu X, et al. Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS. Sci Rep. 2021 Sep 13;11(1):18173.|[5]Umbrasas D, et al. Effects of itaconic acid on neuronal viability and brain mitochondrial functions. J Bioenerg Biomembr. 2021 Oct;53(5):499-511.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  97-65-4