Lys05

Lys05

• Alternative Name: Lys01 (trihydrochloride)
• CAS Number: 1391426-24-6
• UNSPSC Description: Lys05 (Lys01 trihydrochloride) is a novel lysosomal autophagy inhibitor with IC50 values of 3.6, 3.8, 6 and 7.9 μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay.
• Target Antigen: Autophagy
• Type: Reference compound
• Related Pathways: Autophagy
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/Lys01__trihydrochloride_.html
• Purity: 99.89
• Solubility: DMSO : 5.88 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 6.4 mg/mL (ultrasonic)
• Smiles: CN(CCNC1=CC=NC2=C1C=CC(Cl)=C2)CCNC3=CC=NC4=CC(Cl)=CC=C43.[H]Cl.[H]Cl.[H]Cl
• Molecular Weight: 549.75
• References & Citations: [1]McAfee Q, et al. Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8253-8.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported