Products for Research Use Only
RegisterLogin

Isradipine-d3

CAT: 0804-HY-B0233S-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-B0233S-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Isradipine-d3 (PN 200-110-d3) is the deuterium labeled Isradipine. Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease[1][2][3].
CAS Number
1189959-59-8
UNSPSC
12352005
Target
Autophagy; Calcium Channel; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
C(OC(C)C)(=O)C=1C(C(C(OC([2H])([2H])[2H])=O)=C(C)NC1C)C=2C=3C(C=CC2)=NON3
Molecular Formula
C19H18D3N3O5
Molecular Weight
374.41
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Ilijic E, et al. The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease. Neurobiol Dis. 2011;43 (2) :364-371.|[3]Campbell CA, et al. Effects of isradipine, an L-type calcium channel blocker on permanent and transient focal cerebral ischemia in spontaneously hypertensive rats. Exp Neurol. 1997;148 (1) :45-50.|[4]Hof RP, et al. Selective effects of PN 200-110 (isradipine) on the peripheral circulation and the heart. Am J Cardiol. 1987;59 (3) :30B-36B.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-B0233-01Isradipine
HY-B0233S1Isradipine-d6
HY-B0233R-01Isradipine (Standard)
HY-B0233S2Isradipine-d7
HY-15398S3-01Vitamin D3-d3
HY-132348S1Granisetron-d3 (1-methyl-d3)
HY-150954SL-Methionine-d3 (S-methyl-d3) Methyl-d3-sulfonium Chloride
HY-W758392(±) -Ipratropium-d3 Bromide (N-methyl-d3)
HY-B1213AS-01Trimipramine-d3 (N-methyl-d3) (maleate)
HY-104074SPocapavir-d3

Alternative Products

CatalogName
TRC-I925002-1MGIsradipine-d3
AR-I01930-01Isradipine d3
255534-01Isradipine

Popular Products