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Isradipine

CAT: 0804-HY-B0233-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0233-01Size:5 mg
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Description
Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease[1][2][3].
CAS Number
75695-93-1
Product Name Alternative
PN 200-110
UNSPSC
12352005
Hazard Statement
H317, H319
Target
Autophagy; Calcium Channel
Type
Reference compound
Related Pathways
Autophagy; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/isradipine.html
Purity
99.97
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(C1=C(C)NC(C)=C(C(OC(C)C)=O)C1C2=CC=CC3=NON=C23)OC
Molecular Formula
C19H21N3O5
Molecular Weight
371.39
Precautions
H317, H319
References & Citations
[1]Ilijic E, et al. The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease. Neurobiol Dis. 2011;43 (2) :364-371.|[2]Campbell CA, et al. Effects of isradipine, an L-type calcium channel blocker on permanent and transient focal cerebral ischemia in spontaneously hypertensive rats. Exp Neurol. 1997;148 (1) :45-50.|[3]Hof RP, et al. Selective effects of PN 200-110 (isradipine) on the peripheral circulation and the heart. Am J Cardiol. 1987;59 (3) :30B-36B.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
L-type calcium channel

Alternative Products

CatalogName
255534-01Isradipine

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