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Recombinant Human HspH1

CAT: 0014-11124P-1Size: 1000 µgDry Ice: NoHazardous: No
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CAT#:0014-11124P-1Size:1000 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recombinant Human HspH1
CAS Number
9000-83-3
Product Name Alternative
Hsp105
Gene Name
HSPH1
UniProt
Q92598
Cellular Locus
Cytoplasm
Reactivity
Human
Target Antigen
Heat shock protein 105 kDa
Target
HspH1
Type
Protein
Applications
WB
Concentration
Lot Specific
Dilution
Dilute in PBS or medium that is identical to that used in the assay system.
Form
Liquid
Buffer
20 mM Tris
Function
Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). {UniProtKB:Q60446, UniProtKB:Q61699, PubMed:24318877}.
Storage Conditions
Store at 4°C if entire vial will be used within 2-4 weeks. Store at or below - 20°C for longer periods of time. Addition of a carrier protein (such as 0.1% HSA or BSA) is recommended for long-term storage.
Specificity
HspH1
Formulation
Sterile-filtered colorless solution in 20mM Tris-HCl, pH 8.0, and 50mM NaCl.
Buffer pH
pH 8.0
Target Background
HspH1 is a member of the mammalian Hsp105/110 family, a subgroup of the Hsp70 family. Two isoforms of HspH1, alpha and beta, have been identified. HspH1 associates with Hsp70/Hsc70 as complexes and negatively regulates the chaperone activity of Hsp70/Hsc70 in vivo and in vitro. HspH1 is highly expressed in many human tumors.

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