Thalidomide-5-CH2-NH2 (hydrochloride)

Thalidomide-5-CH2-NH2 (hydrochloride)

• CAS Number: 1010100-22-7
• UNSPSC Description: Thalidomide-5-CH2-NH2 (hydrochloride) is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-CH2-NH2 (hydrochloride) can be connected to the ligand for protein by a linker to form PROTACs[1].
• Target Antigen: Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: Apoptosis;Autophagy;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/thalidomide-5-ch2-nh2-hydrochloride.html
• Purity: 98.55
• Solubility: 10 mM in DMSO
• Smiles: NCC1=CC(C(N(C2C(NC(CC2)=O)=O)C3=O)=O)=C3C=C1.Cl
• Molecular Weight: 323.73
• References & Citations: [1]Makbul C, Nassal M, Böttcher B. Slowly folding surface extension in the prototypic avian hepatitis B virus capsid governs stability. Elife. 2020;9:e57277. Published 2020 Aug 14.|[2]Sato T, Ito T, Handa H. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.
• Shipping Conditions: Room Temperature
• Storage Conditions: Store at room temperature, keep dry and cool
• Clinical Information: No Development Reported