Uridine triphosphate

Uridine triphosphate

• CAS Number: 63-39-8
• UNSPSC Description: Uridine triphosphate (UTP) is a pyrimidine nucleoside triphosphate that is used as a substrate to synthesize RNA or as an energy source in metabolic reactions. Uridine triphosphate activates membrane-bound P2Y2 receptors[1][2].
• Target Antigen: DNA/RNA Synthesis; Endogenous Metabolite; P2Y Receptor
• Type: Natural Products
• Related Pathways: Cell Cycle/DNA Damage;GPCR/G Protein;Metabolic Enzyme/Protease
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer; Inflammation/Immunology; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/Uridine_triphosphate.html
• Purity: 70.0
• Solubility: H2O : ≥ 150 mg/mL
• Smiles: O=C(N1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(O)(OP(OP(O)(O)=O)(O)=O)=O)O2)NC(C=C1)=O
• Molecular Weight: 484.14
• References & Citations: [1]Lamarca A, et al. Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation. PLoS One. 2014 Jun 6;9(6):e98998.|[2]Choi JH, et al. Uridine triphosphate increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor. Pancreas. 2013 May;42(4):680-6.|[3]Yitzhaki S, et al. Uridine-5'-triphosphate (UTP) reduces infarct size and improves rat heart function aftermyocardial infarct. Biochem Pharmacol. 2006 Oct 16;72(8):949-55.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Phase 3