Embelin (Standard)

Embelin (Standard)

• CAS Number: 550-24-3
• UNSPSC Description: Embelin (Standard) is the analytical standard of Embelin. This product is intended for research and analytical applications. Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC50=4.1 μM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP. Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Embelin also induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells[1][2][3].
• Target Antigen: Apoptosis; Autophagy; IAP; NF-κB
• Type: Reference Standards
• Related Pathways: Apoptosis;Autophagy;NF-κB
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/embelin-standard.html
• Smiles: O=C1C(O)=C(CCCCCCCCCCC)C(C(O)=C1)=O
• Molecular Weight: 294.39
• References & Citations: [1]Nikolovska-Coleska Z, et al. Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database. J Med Chem. 2004;47(10):2430-2440.|[2]Ahn KS, et al. Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-kappaB (NF-kappaB) signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Mol Pharmacol. 2007;71(1):209-219.|[3]Lee YJ, et al. XIAP inhibitor embelin induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells. Environ Toxicol. 2017;32(11):2371-2378.
• Shipping Conditions: Room temperature