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Embelin

CAT: 0804-HY-17473-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17473-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC50=4.1 μM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP. Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Embelin also induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells[1][2][3].
CAS Number
550-24-3
Product Name Alternative
Embelic acid; Emberine; NSC 91874
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; IAP; NF-κB
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/embelin.html
Purity
99.01
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C1C(O)=C(CCCCCCCCCCC)C(C(O)=C1)=O
Molecular Formula
C17H26O4
Molecular Weight
294.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Nikolovska-Coleska Z, et al. Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database. J Med Chem. 2004;47 (10) :2430-2440.|[2]Ahn KS, et al. Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-kappaB (NF-kappaB) signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Mol Pharmacol. 2007;71 (1) :209-219.|[3]Lee YJ, et al. XIAP inhibitor embelin induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells. Environ Toxicol. 2017;32 (11) :2371-2378.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
XIAP

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