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MC3343

CAT: 0804-HY-124588-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124588-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MC3343, a DNMT inhibitor (EC50 of 5.7 μM) and a strong DNA binder, affects tumor proliferation by blocking OS cells in G1 or G2/M phases and induces osteoblastic differentiation through the specific re-expression of genes regulating this physiological process[1].
CAS Number
1535187-91-7
UNSPSC
12352005
Target
DNA Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mc3343.html
Smiles
O=C(C1=CC(NC2=C3C=CC=CC3=NC=C2)=CC=C1)NC4=CC(NC5=NC(N)=NC(C)=C5)=CC=C4
Molecular Formula
C27H23N7O
Molecular Weight
461.52
References & Citations
[1]Maria Cristina Manara, et al. A Quinoline-Based DNA Methyltransferase Inhibitor as a Possible Adjuvant in Osteosarcoma Therapy. Mol Cancer Ther. 2018 Sep;17 (9) :1881-1892.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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