Recombinant Human CCL28, biotinylated

Recombinant Human CCL28, biotinylated

• Description: Recombinant human CCL28
• Product Name Alternative: rHuCCL28-biotin, MEC
• CAS Number: 9000-83-3
• Gene Name: CCL28
• UniProt: Q9NRJ3
• Cellular Locus: Secreted.
• Reactivity: Human
• Target Antigen: C-C motif chemokine 28
• Target: CCL28ylated
• Type: Protein
• Applications: Migration assay
• Dilution: Centrifuge tube prior to resuspending. Recommended at 100ug/ml in sterile distilled water.
• Form: Lyophilized
• Function: Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.
• Additionnal Information: Endotoxin Level: <0.01 EU per 1ug of protein by LAL method.Migration Assay of recombinant cells expressing CCR10.
• Storage Conditions: 12 months from date of receipt, -20°C to -70°C, as supplied. 1 month, -20°C to -70°C, under sterile conditions after reconstitution. Best if used immediately after reconstitution. Avoid multiple freeze-thaw cycles.
• Specificity: CCL28ylated
• Target Background: CCL28, also known as Mucosae-associated Epithelial Chemokine (MEC), is secreted by gastrointestinal and non-intestinal mucosal cells. It regulates chemotaxis of cells expressing surface receptors CCR3 and CCR10. This chemokine is constitutively expressed in the colon, but its levels can be increased by pro-inflammatory cytokines and certain bacterial products implying a role in effector cell recruitment to sites of epithelial injury. CCL28 has also been implicated in the migration of IgA-expressing cells to the mammary gland, salivary gland, intestine and other mucosal tissues. It has also been shown as a potential antimicrobial agent effective against certain pathogens, such as Gram negative and Gram positive bacteria and the fungus Candida albicans.