Products for Research Use Only
RegisterLogin

GW2580-d6

CAT: 0804-HY-10917S-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-10917S-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
GW2580-d6 is the deuterium labeled GW2580. GW2580 is an orally bioavailable and selective inhibitor of c-Fms kinase which completely inhibits human cFMS kinase in vitro at 0.06 μM. GW2580 acts as a competitive inhibitor of ATP binding to the cFMS kinase and inhibits colony-stimulating-factor-1 signaling[1].
CAS Number
2733770-48-2
UNSPSC
12352005
Target
C-Fms; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Field of Research
Inflammation/Immunology; Cancer
Purity
98.36
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC1=NC(N)=C(CC2=CC(OC([2H])([2H])[2H])=C(OCC3=CC=C(OC([2H])([2H])[2H])C=C3)C=C2)C=N1
Molecular Formula
C20H16D6N4O3
Molecular Weight
372.45
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Conway JG, et al. Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc Natl Acad Sci U S A. 2005 Nov 1;102 (44) :16078-83.|[3]Priceman SJ, et al. Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy. Blood. 2010 Feb 18;115 (7) :1461-71|[4]Conway JG, et al. Effects of the cFMS kinase inhibitor 5- (3-methoxy-4- ((4-methoxybenzyl) oxy) benzyl) pyrimidine-2,4-diamine (GW2580) in normal and arthritic rats. J Pharmacol Exp Ther. 2008 Jul;326 (1) :41-50.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-10917-01GW2580
HY-10917R-01GW2580 (Standard)
HY-110225-01Levetiracetam-d6 (ring-d6)
HY-N0893STetrahydrocurcumin-d6
HY-W750155Tetramethrin-d6
HY-W744578Taurolidine-d6
HY-W744275Tipelukast-d6
HY-W704964-01Dimethylcyanamide-d6
HY-W010201SCitronellol-d6
HY-N0709S1Coumarin-d6

Alternative Products

CatalogName
1740-5GW2580
A11959-200GW2580 200mg
A11959-50GW2580 50mg
A11959-100GW2580 100mg
A11959-25GW2580 25mg

Popular Products