STAT3-IN-13

STAT3-IN-13

• CAS Number: 2248552-86-3
• UNSPSC Description: STAT3-IN-13 (compound 6f) is a potent STAT3 inhibitor. STAT3-IN-13 has anti-proliferative effects and binds to the STAT3 SH2 domain with a KD of 0.46 μM. STAT3-IN-13 inhibits the phosphorylation of STAT3 Y705 and downstream target gene expression. STAT3-IN-13 induces apoptosis in vitro and suppresses the growth and metastasis of tumor in vivo. STAT3-IN-13 can be used for cancer research[1].
• Target Antigen: Apoptosis; Bcl-2 Family; STAT
• Type: Reference compound
• Related Pathways: Apoptosis;JAK/STAT Signaling;Stem Cell/Wnt
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/stat3-in-13.html
• Solubility: DMSO : 125 mg/mL (ultrasonic)
• Smiles: N#CC1=C(SC2=C1CCN(C2)C(NC3=CC=C(C=C3)OC)=O)NC(C(C=N4)=CN4C)=O
• Molecular Weight: 436.49
• References & Citations: [1]Jin W, et, al. Discovery of 2-Amino-3-cyanothiophene Derivatives as Potent STAT3 Inhibitors for the Treatment of Osteosarcoma Growth and Metastasis. J Med Chem. 2022 May 12;65(9):6710-6728.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported