Inosine

• Description:

  Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors[1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Adenosine Receptor; Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  GPCR/G Protein; Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Inflammation/Immunology; Neurological Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Inosine.html

• Concentration:

  10mM

• Purity:

  99.94

• Solubility:

  DMSO : 25 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic)

• Smiles:

  O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C=NC3=C2N=CNC3=O

• Molecular Formula:

  C10H12N4O5

• Molecular Weight:

  268.23

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Filipe Marques Gonçalves, et al. Signaling pathways underlying the antidepressant-like effect of inosine in mice. Purinergic Signal. 2017 Jun; 13 (2) : 203-214.|[2]Ajith A. Welihinda, et al. The adenosine metabolite inosine is a functional agonist of the adenosine A2A receptor with a unique signaling bias. Cell Signal. 2016 Jun; 28 (6) : 552-560.|[3]Francisney Pinto Nascimento, et al. Adenosine A1 receptor-dependent antinociception induced by inosine in mice: pharmacological, genetic and biochemical aspects. Mol Neurobiol. 2015;51 (3) :1368-78.|[4]Sara Cipriani, et al. Protection by inosine in a cellular model of Parkinson’s disease. Neuroscience. 2014 Aug 22; 274: 242-249.|[5]Preitner F, et al. Urate-induced acute renal failure and chronic inflammation in liver-specific Glut9 knockout mice. Am J Physiol Renal Physiol. 2013 Sep 1;305 (5) :F786-95.|[6]Tang DH, et al. Inosine induces acute hyperuricaemia in rhesus monkey (Macaca mulatta) as a potential disease animal model. Pharm Biol. 2021 Dec;59 (1) :175-182.|[7]Zhao H, et al. Lacticaseibacillus rhamnosus Fmb14 prevents purine induced hyperuricemia and alleviate renal fibrosis through gut-kidney axis. Pharmacol Res. 2022 Aug;182:106350.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• Isoform:

  Adenosine A1 receptor (A1R) ; Adenosine A2A receptor (A2AR) ; Human Endogenous Metabolite

• CAS Number:

  [58-63-9]