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Boc-C1-PEG3-C4-OH

CAT: 0804-HY-130618-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-130618-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Boc-C1-PEG3-C4-OH is a PROTAC linker, which refers to the Alkyl/ether composition. Boc-C1-PEG3-C4-OH can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
CAS Number
2376724-97-7
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/boc-c1-peg3-c4-oh.html
Purity
95.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(OC(C)(C)C)COCCOCCOCCCCCCO
Molecular Formula
C16H32O6
Molecular Weight
320.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. ACS Chem Biol. 2019 Sep 20;14 (9) :2024-2034.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Alkyl/ether Linkers

Chemical Information

Boc-C1-PEG3-C4-OH
CAS Number2376724-97-7
PubChem CID145712398
IUPAC Nametert-butyl 2-[2-[2-(6-hydroxyhexoxy)ethoxy]ethoxy]acetate
Molecular FormulaC16H32O6
Molecular Weight320.42
XLogP1.4
Topological Polar Surface Area74.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count16
Heavy Atom Count22
Formal Charge0
Complexity262
SMILES
CC(C)(C)OC(=O)COCCOCCOCCCCCCO
InChI
InChI=1S/C16H32O6/c1-16(2,3)22-15(18)14-21-13-12-20-11-10-19-9-7-5-4-6-8-17/h17H,4-14H2,1-3H3
InChIKey
RFJQECXXHSDFPN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Boc-C1-PEG3-C4-OH
CAS: 2376724-97-7
CID: 145712398
Formula: C16H32O6
MW: 320.42
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight320.42
XLogP31.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count16
Exact Mass320.21988874
Monoisotopic Mass320.21988874
Topological Polar Surface Area74.2 Ų
Heavy Atom Count22
Formal Charge0
Complexity262
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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