Nitidine (chloride) (Standard)

• UNSPSC Description:

  Nitidine (chloride) (Standard) is the analytical standard of Nitidine (chloride). This product is intended for research and analytical applications. Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway[1][2][3][4][5][6].

• Target Antigen:

  Apoptosis; ERK; FAK; NF-κB; p38 MAPK; Parasite; STAT; Topoisomerase

• Type:

  Reference Standards

• Related Pathways:

  Anti-infection;Apoptosis;Cell Cycle/DNA Damage;JAK/STAT Signaling;MAPK/ERK Pathway;NF-κB;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/nitidine-chloride-standard.html

• Smiles:

  C[N+]1=CC2=CC(OC)=C(OC)C=C2C(C=CC3=C4)=C1C3=CC5=C4OCO5.[Cl-]

• Molecular Weight:

  383.82

• References & Citations:

  [1]Chen J, et al. Inhibition of STAT3 signaling pathway by nitidine chloride suppressed the angiogenesis and growth of human gastric cancer. Mol Cancer Ther. 2012 Feb;11(2):277-87.|[2]Wang Z, et al. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kappaB pathway in RAW 264.7 cells. J Ethnopharmacol. 2012 Oct 31;144(1):145-50.|[3]Pan X, et al. Nitidine Chloride inhibits breast cancer cells migration and invasion by suppressing c-Src/FAK associated signaling pathway. Cancer Lett. 2011 Dec 27;313(2):181-91.|[4]Fang Z, et al. Nitidine chloride induces apoptosis and inhibits tumor cell proliferation via suppressing ERK signaling pathway in renal cancer. Food Chem Toxicol. 2014 Apr;66:210-6.|[5]Liu LM, et al. DNA topoisomerase 1 and 2A function as oncogenes in liver cancer and may be direct targets of nitidine chloride. Int J Oncol. 2018 Nov;53(5):1897-1912.|[6]Bouquet J, et al. Biological activities of nitidine, a potential anti-malarial lead compound. Malar J. 2012 Mar 9;11:67.

• Shipping Conditions:

  Room temperature

• CAS Number:

  13063-04-2