NE-100 hydrochloride

CAT: 0026-B3047-1Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0026-B3047-1Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

NE-100 is a potent antagonist of sigma-1 (σ1) receptor. It inhibits binding of (+)-pentazocine binding to sigma-1 binding sites with an IC₅₀ value of 1.54 nM. NE-100 attenuates phencyclidin induced head-weaving behavior or ataxia in experimental animals. It suppresses ER stress-induced cell death by the upregulation of 78-kDa glucose-regulated protein (GRP78). Modulators of sigma receptors are suggested to show activity against SARS-CoV-2, based on interaction of SARS-CoV-2 proteins Nsp6 and Orf9c with sigma receptors.

Shipping Conditions

Storage Conditions

-20ºC

Shelf Life

36 months

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NE-100 hydrochloride

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