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Adaptaquin

CAT: 0026-B2706-5Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0026-B2706-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Adaptaquin is a brain-permeable hypoxia-inducible factor (HIF) prolyl hydroxylase 2 (PHD2) inhibitor. It stabilizes HIF-1α protein and induces expression of the HIF-1-regulated genes EPO and VEGF in SH-SY5Y human neuroblastoma cells. Adaptaquin protects against cell death induced by glutathione depletion in rat primary cortical neurons (IC50 = 0.25 μM) and reduces glutamate-induced cell death in HT-22 cells. Displays neuroprotective effects and enhances functional recovery in rodent intracerebral hemorrhage models, via inhibition of ATF4 dependent genes. Also acts as an antioxidant.
Shipping Conditions
Gel Pack
Storage Conditions
-20ºC
Shelf Life
36 months

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