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Adaptaquin (Standard)

CAT: 0804-HY-101449RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101449RSize:1 Each
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Description
Adaptaquin (Standard) is the analytical standard of Adaptaquin. This product is intended for research and analytical applications. Adaptaquin is a BBB-penetrable HIF-PHDs inhibitor. Adaptaquin has anti-inflammatory and neuroprotective effects. Adaptaquin can effectively inhibit lipid peroxidation, maintain mitochondrial function, and reduce neuronal death. Adaptaquin can be used in the research of nervous system diseases such as Parkinson's disease[1][2][3].
CAS Number
385786-48-1
Target
HIF/HIF Prolyl-Hydroxylase; Reactive Oxygen Species (ROS) ; Reference Standards
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others
Field of Research
Metabolic Disease; Inflammation/Immunology; Neurological Disease
Smiles
OC1=C2N=CC=CC2=CC=C1C(C3=CC=C(Cl)C=C3)NC4=NC=CC=C4O
Molecular Formula
C21H16ClN3O2
Molecular Weight
377.82
References & Citations
[1]Neitemeier S, et, al. Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis. Cell Death Dis. 2016 May 5;7 (5) :e2214.|[2]Aimé P, et al. The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson's disease. Neurobiol Dis. 2020 Mar;136:104725.|[3]Karuppagounder SS, et al. Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models. Sci Transl Med. 2016 Mar 2;8 (328) :328ra29.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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