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AMTB (hydrochloride)

CAT: 0804-HY-100345-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100345-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AMTB hydrochloride is a selective TRPM8 channel blocker. AMTB hydrochloride inhibits icilin-induced TRPM8 channel activation with a pIC50 of 6.23. AMTB hydrochloride can be used for the research of the overactive bladder and painful bladder syndrome. AMTB hydrochloride is a non-selective inhibitor of voltage-gated sodium channels (NaV) [1][2].
CAS Number
926023-82-7
UNSPSC
12352005
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/amtb-hydrochloride.html
Purity
99.18
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N(CCCN)CC1=CC=CS1)C2=CC=CC=C2OCC3=CC=CC(C)=C3.[H]Cl
Molecular Formula
C23H27ClN2O2S
Molecular Weight
430.99
References & Citations
[1]Lashinger ES, et al. AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome. Am J Physiol Renal Physiol. 2008;295 (3) :F803-F810. |[2]Yapa KTDS, et al. Assessment of the TRPM8 inhibitor AMTB in breast cancer cells and its identification as an inhibitor of voltage gated sodium channels. Life Sci. 2018;198:128-135.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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