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JNJ-47965567

CAT: 0026-B2972-25Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0026-B2972-25Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JNJ-47965567 is a potent and selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel. Activation of P2X receptors by BzATP induces calcium flux. JNJ-47965567 attenuates Bz-ATP induced calcium flux in 1321N1 astrocytoma cells transfected with the recombinant P2X7 proteins with pIC₅₀ values of 8.3, 7.5 and 7.2 for human, mouse and rat receptors respectively. JNJ-47965567 (30 mg/kg for 5 days) significantly reduces spontaneous seizures in epileptic mice even after treatment is stopped.
Shipping Conditions
RT
Storage Conditions
-20ºC
Shelf Life
36 months

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