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PLX5622 (free base)

CAT: 0026-B2965-5Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0026-B2965-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PLX5622 is an inhibitor of colony-stimulating factor 1 receptor (CSF1R) tyrosine kinase with a Ki of 5.9 nM. It causes sustained and specific elimination of microglia. As a result of microglial depletion, plaques fail to form in the parenchymal space in the 5xFAD mouse model of Alzheimer’s disease (AD). Inhibition of the CSF1R at lower doses in 3xTg-AD mice prevents microglial association with plaques and improves cognition.
Shipping Conditions
RT
Storage Conditions
-20ºC
Shelf Life
36 months

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