Flubendazole

CAT: 0026-B2955-5Size: 5 mgDry Ice: NoHazardous: No
CAT#:0026-B2955-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Flubendazole is a benzimidazole carbamate anthelmintic agent. It eliminates larvae in a mouse model of A. cantonensis infection and exhibits a mean larval reduction of 100% in a T. spiralis infection model when administered at doses of 5 and 50 mg/kg per day, respectively. It disrupts tubulin polymerization by showing preference for binding to nematode tubulin rather than the tubulin in host. Flubendazole inhibits mammalian tubulin polymerization with an IC₅₀ of 2.5 µM. The microtubule-disrupting properties of benzimidazoles cause potential anti-cancer activity. The IC₅₀ values for inhibition of proliferation of MDA-MB-231, BT-549, MCF-7 and SK-BR-3 cells are 1.75 μM, 0.72 μM, 5.51 μM and 1.51 μM, respectively.
Shipping Conditions
RT
Storage Conditions
-20ºC
Shelf Life
36months

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