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2-Hydroxycinnamic acid

CAT: 0804-HY-W012531-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W012531-01Size:100 mg
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Description
2-Hydroxycinnamic acid is a phenolic acid with antimicrobial and antioxidant properties. 2-Hydroxycinnamic acid has antimicrobial activity against Staphylococcus aureus and is not susceptible to drug resistance. 2-Hydroxycinnamic acid shows inhibitory effects on infection of HIV/SARS-CoV S pseudovirus with an IC50 of 0.3 mM. In addition, 2-Hydroxycinnamic acid has neuroprotective and antitumor activity[1][2][3][4].
CAS Number
[614-60-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial; Endogenous Metabolite; HIV; SARS-CoV
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/2-hydroxycinnamic-acid.html
Purity
99.86
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)/C=C/C1=CC=CC=C1O
Molecular Formula
C9H8O3
Molecular Weight
164.16
Precautions
H302, H315, H319, H335
References & Citations
[1]Tran Minh Ngoc, et al. A new coumarin and cytotoxic activities of constituents from Cinnamomum cassia. Nat Prod Commun. 2014 Apr;9 (4) :487-8.|[2]Min Zhuang, et al. Procyanidins and butanol extract of Cinnamomi Cortex inhibit SARS-CoV infection. Antiviral Res. 2009 Apr;82 (1) :73-81.|[3]Keman D, et al. Antibiotic-Resistant Staphylococcus aureus Does Not Develop Resistance to Vanillic Acid and 2-Hydroxycinnamic Acid after Continuous Exposure in Vitro. ACS Omega. 2019 Sep 10;4 (13) :15393-15400.|[4]Hao S, et al. Hydroxycinnamic Acid from Corncob and Its Structural Analogues Inhibit Aβ40 Fibrillation and Attenuate Aβ40-Induced Cytotoxicity. J Agric Food Chem. 2020 Aug 19;68 (33) :8788-8796.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
HIV

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