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α-Cyano-4-hydroxycinnamic acid

CAT: 0804-HY-107641-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107641-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs) . α-Cyano-4-hydroxycinnamic acid inhibits mitochondrial pyruvate transporter with a Ki of 6.3 μM. α-Cyano-4-hydroxycinnamic acid is used as a matrix to facilitate peptide ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications[1][2].
CAS Number
28166-41-8
Product Name Alternative
α-Cyano-4-hydroxycinnamate
UNSPSC
12352005
Hazard Statement
H315, H317, H319, H335
Target
Monocarboxylate Transporter
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/α-cyano-4-hydroxycinnamic-acid.html
Purity
99.92
Solubility
DMSO : 200 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O)/C(C#N)=C/C1=CC=C(O)C=C1
Molecular Formula
C10H7NO3
Molecular Weight
189.17
Precautions
H315, H317, H319, H335
References & Citations
[1]A P Halestrap, et al. The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors. Biochem J. 1975 Apr; 148 (1) : 85-96.|[2]Sara Granja, et al. The Monocarboxylate Transporter Inhibitor α-cyano-4-hydroxycinnamic Acid Disrupts Rat Lung Branching. Cell Physiol Biochem. 2013;32 (6) :1845-56.|[3]Makoto Watanabe, et al. Improvement of Mass Spectrometry Analysis of Glycoproteins by MALDI-MS Using 3-aminoquinoline/α-cyano-4-hydroxycinnamic Acid. Anal Bioanal Chem. 2013 May;405 (12) :4289-93.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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