1-Deoxynojirimycin (hydrochloride)

1-Deoxynojirimycin (hydrochloride)

• CAS Number: 73285-50-4
• UNSPSC Description: 1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin hydrochloride suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin hydrochloride possesses antihyperglycemic, anti-obesity, and antiviral features[1][2].
• Target Antigen: Antibiotic; Bacterial; Glycosidase; PI3K
• Type: Natural Products
• Related Pathways: Anti-infection;Metabolic Enzyme/Protease;PI3K/Akt/mTOR
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Infection; Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/1-deoxynojirimycin-hydrochloride.html
• Solubility: H2O : 250 mg/mL (ultrasonic)
• Smiles: O[C@@H]1[C@@H](CO)NC[C@H](O)[C@H]1O.[H]Cl
• Molecular Weight: 199.63
• References & Citations: [1]Gao K, et al. 1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing. Molecules. 2016 Nov 23;21(11). pii: E1600.|[2]Chaluntorn Vichasilp,et al. Development of high 1-deoxynojirimycin (DNJ) content mulberry tea and use of response surface methodology to optimize tea-making conditions for highest DNJ extraction. LWT - Food Science and Technology. Volume 45, Issue 2, March 2012, Pages 226-232.|[3]Liu Q, et al. 1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice. Molecules. 2015 Dec 4;20(12):21700-14.
• Shipping Conditions: Room Temperature
• Clinical Information: Phase 2