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Terfenadine

CAT: 0804-HY-B1193-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1193-01Size:100 mg
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Description
Terfenadine ((±) -Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM[1]. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9[2].
CAS Number
50679-08-8
Product Name Alternative
(±) -Terfenadine; MDL-991
UNSPSC
12352005
Hazard Statement
H413
Target
Apoptosis; Caspase; Histamine Receptor; Na+/Ca2+ Exchanger; Potassium Channel
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Terfenadine.html
Concentration
10mM
Purity
99.98
Solubility
DMSO : ≥ 50 mg/mL|H2O : < 0.1 mg/mL
Smiles
OC(C1=CC=C(C(C)(C)C)C=C1)CCCN2CCC(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)CC2
Molecular Formula
C32H41NO2
Molecular Weight
471.67
Precautions
H413
References & Citations
[1]Kamiya K, et al. Molecular determinants of hERG channel block by terfenadine and cisapride. J Pharmacol Sci. 2008 Nov;108 (3) :301-307.|[2]Nicolau-Galmés F, et al. Terfenadine induces apoptosis and autophagy in melanoma cells through ROS-dependent and -independent mechanisms. Apoptosis. 2011 Dec;16 (12) :1253-67.|[3]An L, et al. Terfenadine combined with epirubicin impedes the chemo-resistant human non-small cell lung cancer both in vitro and in vivo through EMT and Notch reversal. Pharmacol Res. 2017 Oct;124:105-115.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Caspase 2; Caspase 4; Caspase 9; H1 Receptor

Alternative Products

CatalogName
MBS6106930-01Terfenadine

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