Products for Research Use Only
RegisterLogin

Terfenadine-d3

CAT: 0804-HY-B1193S-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-B1193S-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Terfenadine-d3 ((±) -Terfenadine-d3) is the deuterium labeled Terfenadine. Terfenadine ((±) -Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM[1]. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9[2].
CAS Number
192584-82-0
UNSPSC
12352005
Target
Apoptosis; Caspase; Histamine Receptor; Isotope-Labeled Compounds; Na+/Ca2+ Exchanger; Potassium Channel
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Inflammation/Immunology; Endocrinology
Solubility
10 mM in DMSO
Smiles
C(O)(C1CCN(CCC(C(O)(C2=CC=C(C(C)(C)C)C=C2)[2H])([2H])[2H])CC1)(C3=CC=CC=C3)C4=CC=CC=C4
Molecular Formula
C32H38D3NO2
Molecular Weight
474.69
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Kamiya K, et al. Molecular determinants of hERG channel block by terfenadine and cisapride. J Pharmacol Sci. 2008 Nov;108 (3) :301-307.|[3]Nicolau-Galmés F, et al. Terfenadine induces apoptosis and autophagy in melanoma cells through ROS-dependent and -independent mechanisms. Apoptosis. 2011 Dec;16 (12) :1253-67.|[4]An L, et al. Terfenadine combined with epirubicin impedes the chemo-resistant human non-small cell lung cancer both in vitro and in vivo through EMT and Notch reversal. Pharmacol Res. 2017 Oct;124:105-115.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
H1 Receptor

Related Products

CatalogName
HY-B1193-01Terfenadine
HY-B1193R-01Terfenadine (Standard)
HY-15398S3-01Vitamin D3-d3
HY-132348S1Granisetron-d3 (1-methyl-d3)
HY-150954SL-Methionine-d3 (S-methyl-d3) Methyl-d3-sulfonium Chloride
HY-W758392(±) -Ipratropium-d3 Bromide (N-methyl-d3)
HY-B1213AS-01Trimipramine-d3 (N-methyl-d3) (maleate)
HY-17373S2Posaconazole-d3
HY-15345ASTetrahydrouridine-d3
HY-14771SImeglimin-d3

Alternative Products

CatalogName
467007-01Terfenadine-d3
MBS6106930-01Terfenadine

Popular Products