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Domiphen (bromide)

CAT: 0804-HY-B1467-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1467-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Domiphen bromide is a cationic active quaternary ammonium salt and also an inhibitor of HERG channels (IC50: 9 nM), aminopeptidase-like enzymes, Escherichia coli alkaline phosphatase, and α-chymotrypsin. Domiphen bromide has multiple activities such as antibacterial, antimalarial, and disinfectant properties, and it is also a synergist of Colistin. Domiphen bromide can be used as a chemical preservative and a cationic surfactant, and it can also be used in the research of bacterial infectious diseases such as pharyngitis, thrush, and oral ulcers[1][2][3][4][5].
CAS Number
538-71-6
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Bacterial; Parasite; Phosphatase; Potassium Channel
Type
Reference compound
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Domiphen-bromide.html
Purity
99.61
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
CCCCCCCCCCCC[N+](C)(C)CCOC1=CC=CC=C1.[Br-]
Molecular Formula
C22H40BrNO
Molecular Weight
414.46
Precautions
H315, H319, H335
References & Citations
[1]Biosca A, et al. Characterization of Domiphen Bromide as a New Fast-Acting Antiplasmodial Agent Inhibiting the Apicoplastidic Methyl Erythritol Phosphate Pathway. Pharmaceutics. 2022 Jun 22;14 (7) :1320.|[2]Chen H, et al. Combining with domiphen bromide restores colistin efficacy against colistin-resistant Gram-negative bacteria in vitro and in vivo. Int J Antimicrob Agents. 2024 Feb;63 (2) :107066.|[3]Long Y, et al. Proarrhythmic effects induced by benzethonium chloride and domiphen bromide in vitro and in vivo. Toxicol Appl Pharmacol. 2021 Nov 15;431:115731.|[4]Long Y, et al. Inhibition of HERG potassium channels by domiphen bromide and didecyl dimethylammonium bromide. Eur J Pharmacol. 2014 Aug 15;737:202-9.|[5]Mäkinen KK, et al. Selective effect of domiphen bromide (dodecyldimethyl (2-phenoxyethyl) ammonium bromide) on some hydrolytic enzymes. Biochim Biophys Acta. 1970 Apr 22;206 (1) :143-51.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched

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