Cholestenone-13C

Cholestenone-13C

• Product Name Alternative: (Rac)-Rebemadlin
• CAS Number: 68165-57-1
• UNSPSC Description: Cholestenone-13C is the 13C labeled Cholestenone. Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop and efflux. Cholestenone may cause long-term functional defects in cells[1][2][3].
• Target Antigen: Endogenous Metabolite
• Type: Isotope-Labeled Compounds
• Related Pathways: Metabolic Enzyme/Protease
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/cholestenone-13c.html
• Purity: 99.0
• Solubility: 10 mM in DMSO
• Smiles: C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(CC3)=[13CH]C(CC4)=O)C
• Molecular Weight: 385.63
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Neuvonen M, et, al. Enzymatic oxidation of cholesterol: properties and functional effects of cholestenone in cell membranes. PLoS One. 2014 Aug 26;9(8):e103743.|[3]Rosenheim O, et al. The mechanism of coprosterol formation in vivo: 1. Cholestenone as an intermediate. Biochem J. 1943 Oct;37(4):513-4.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported