Cholestenone-13C2

Cholestenone-13C2

• Product Name Alternative: PF-2545920 (succinate)
• CAS Number: 82938-09-8
• UNSPSC Description: Cholestenone-13C2 is the 13C labeled Cholestenone. Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop and efflux. Cholestenone may cause long-term functional defects in cells[1][2][3].
• Target Antigen: Endogenous Metabolite; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: Metabolic Enzyme/Protease;Others
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/cholestenone-13c2.html
• Solubility: 10 mM in DMSO
• Smiles: CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=[13CH][13C](CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O
• Molecular Weight: 386.62
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Neuvonen M, et, al. Enzymatic oxidation of cholesterol: properties and functional effects of cholestenone in cell membranes. PLoS One. 2014 Aug 26;9(8):e103743.|[3]Rosenheim O, et al. The mechanism of coprosterol formation in vivo: 1. Cholestenone as an intermediate. Biochem J. 1943 Oct;37(4):513-4.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported