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Calceolarioside B

CAT: 0804-HY-N0539-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0539-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Calceolarioside B is a phenylethanoid glycoside. Calceolarioside B can be isolated from the leaves of Akebia quinata. Calceolarioside B inhibits RLAR activity with an IC50 value of 23.99 μM. Calceolarioside B inhibits the entry of Omicron BA.2 into host cells. Calceolarioside B reduces IL-6 levels. Calceolarioside B has immunomodulatory activity. Calceolarioside B has anticancer activity against human hormone-independent prostate cancer[1][2][3][4].
CAS Number
105471-98-5
UNSPSC
12352005
Target
Aldose Reductase; Interleukin Related; SARS-CoV
Type
Natural Products
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/calceolarioside-b.html
Purity
99.93
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O[C@H]([C@@H](O)[C@@H]1O)[C@@H](O[C@@H]1COC(/C=C/C2=CC(O)=C(O)C=C2)=O)OCCC3=CC(O)=C(O)C=C3
Molecular Formula
C23H26O11
Molecular Weight
478.45
References & Citations
[1]Hwang SH, et al. Inhibitory Activities of Stauntonia hexaphylla Leaf Constituents on Rat Lens Aldose Reductase and Formation of Advanced Glycation End Products and Antioxidant. Biomed Res Int. 2017;2017:4273257.|[2]Zheng X, et al. Identification of the functional food ingredients with antithrombotic properties via virtual screen and experimental studies. Food Chem. 2021 Nov 15;362:130237. |[3]Mulani SK, et al. A general synthetic strategy and the anti-proliferation properties on prostate cancer cell lines for natural phenylethanoid glycosides. Org Biomol Chem. 2014 May 14;12 (18) :2926-37. |[4]Lin XB, et al. Calceolarioside B inhibits SARS-CoV-2 Omicron BA.2 variant cell entry and modulates immune response. Virol J. 2024 Dec 21;21 (1) :329.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
IL-6

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