Resminostat (hydrochloride)

Resminostat (hydrochloride)

• CAS Number: 1187075-34-8
• UNSPSC Description: Resminostat hydrochloride is a potent inhibitor of HDAC1, HDAC3 and HDAC6, with mean IC50 values of 42.5, 50.1, 71.8 nM, respectively, and shows less potent activities against HDAC8, with an IC50 of 877 nM.
• Target Antigen: HDAC
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/Resminostat-hydrochloride.html
• Solubility: DMSO : ≥ 50 mg/mL|H2O : 7.14 mg/mL (ultrasonic)
• Smiles: O=C(NO)/C=C/C1=CN(S(=O)(C2=CC=C(CN(C)C)C=C2)=O)C=C1.Cl
• Molecular Weight: 385.87
• References & Citations: [1]Mandl-Weber S, et al. The novel inhibitor of histone deacetylase resminostat (RAS2410) inhibits proliferation and induces apoptosis in multiple myeloma (MM) cells. Br J Haematol. 2010 May;149(4):518-28.|[2]Enzenhofer E, et al. Effect of the histone deacetylase inhibitor resminostat on head and neck squamous cell carcinoma cell lines. Head Neck. 2017 May;39(5):900-907.|[3]Peng X, et al. mTOR inhibition sensitizes human hepatocellular carcinoma cells to resminostat. Biochem Biophys Res Commun. 2016 Sep 2;477(4):556-562.Methods Mol Biol. 2018;1711:351-398.|Acta Pharmacol Sin. 2021 Apr 13.
• Shipping Conditions: Room Temperature
• Clinical Information: Phase 4