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PMED-1

CAT: 0804-HY-164520Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-164520Size:1 Each
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Description
PMED-1 is a β-catenin inhibitor that significantly reduces β-catenin activity in hepatoblastoma cells and various HCC cells, with an IC50 value ranging from 4.87 to 32 μM. PMED-1 affects Wnt signaling by decreasing the interaction between β-catenin and CREB binding protein, thereby inhibiting cell proliferation. PMED-1 has potential applications in cancer research[1].
CAS Number
491828-75-2
UNSPSC
12352005
Target
Wnt
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pmed-1.html
Smiles
O=C(NC1=CN(CC2=CC=C(F)C=C2)N=C1)C(C3)C3C4=CC=CC=C4
Molecular Formula
C20H18FN3O
Molecular Weight
335.37
References & Citations
[1]Delgado ER, et al. Identification and characterization of a novel small-molecule inhibitor of β-catenin signaling. Am J Pathol. 2014 Jul;184 (7) :2111-22.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported