URB-597

• Description:

  URB-597 (KDS-4103) is an orally bioavailable and selective FAAH inhibitor. URB-597 inhibits FAAH activity with an IC50s of approximately 5 nM in rat brain membranes, 0.5 nM in intact rat neurons, 3 nM in human liver microsomes. Antidepressant-like effects. Analgesic activity[1].

• Product Name Alternative:

  KDS-4103

• UNSPSC:

  12352005

• Hazard Statement:

  H319, H410

• Target:

  Autophagy; FAAH; Mitophagy

• Type:

  Reference compound

• Related Pathways:

  Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/URB-597.html

• Purity:

  99.15

• Solubility:

  DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL

• Smiles:

  O=C(OC1=CC(C2=CC=CC(C(N)=O)=C2)=CC=C1)NC3CCCCC3

• Molecular Formula:

  C20H22N2O3

• Molecular Weight:

  338.40

• Precautions:

  H319, H410

• References & Citations:

  [1]Daniele Piomelli, et al. Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597) . CNS Drug Rev. Spring 2006;12 (1) :21-38.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• CAS Number:

  [546141-08-6]