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URB-597

CAT: 0804-HY-10864-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-10864-01Size:5 mg
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Description
URB-597 (KDS-4103) is an orally bioavailable and selective FAAH inhibitor. URB-597 inhibits FAAH activity with an IC50s of approximately 5 nM in rat brain membranes, 0.5 nM in intact rat neurons, 3 nM in human liver microsomes. Antidepressant-like effects. Analgesic activity[1].
CAS Number
[546141-08-6]
Product Name Alternative
KDS-4103
UNSPSC
12352005
Hazard Statement
H319, H410
Target
Autophagy; FAAH; Mitophagy
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/URB-597.html
Purity
99.15
Solubility
DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL
Smiles
O=C(OC1=CC(C2=CC=CC(C(N)=O)=C2)=CC=C1)NC3CCCCC3
Molecular Formula
C20H22N2O3
Molecular Weight
338.40
Precautions
H319, H410
References & Citations
[1]Daniele Piomelli, et al. Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597) . CNS Drug Rev. Spring 2006;12 (1) :21-38.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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