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Astin B

CAT: 0804-HY-P3148Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P3148Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Astin B is a orally active and potent cyclic pentapeptide, that can be isolated from Aster tataricus. Astin B has hepatotoxic effects in vitro and in vivo and that hepatic injury was primarily mediated by apoptosis in a mitochondria/caspase-dependent manner. Astin B induces autophagy in L-02 cells, increases LC3-II and decreases p62 expression[1].
CAS Number
151201-76-2
UNSPSC
12352209
Target
Apoptosis; Atg8/LC3; Autophagy; Bcl-2 Family; Caspase; JNK; p62; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/astin-b.html
Solubility
H2O
Smiles
Cl[C@H](C1)[C@@H](Cl)[C@@](N1C([C@H](CC)NC(C[C@H](C2=CC=CC=C2)N3)=O)=O)([H])C(N[C@H]([C@H](C)O)C(N[C@@H](CO)C3=O)=O)=O
Molecular Formula
C25H33Cl2N5O7
Molecular Weight
586.46
References & Citations
[1]Wang L, et al. Astin B, a cyclic pentapeptide from Aster tataricus, induces apoptosis and autophagy in human hepatic L-02 cells. Chem Biol Interact. 2014 Nov 5;223:1-9.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Bax; Bcl-2; Caspase 3; Caspase 9

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