Astin B

Astin B

• CAS Number: 151201-76-2
• UNSPSC Description: Astin B is a orally active and potent cyclic pentapeptide, that can be isolated from Aster tataricus. Astin B has hepatotoxic effects in vitro and in vivo and that hepatic injury was primarily mediated by apoptosis in a mitochondria/caspase-dependent manner. Astin B induces autophagy in L-02 cells, increases LC3-II and decreases p62 expression[1].
• Target Antigen: Apoptosis; Atg8/LC3; Autophagy; Bcl-2 Family; Caspase; JNK; p62; Reactive Oxygen Species
• Type: Natural Products
• Related Pathways: Apoptosis;Autophagy;Immunology/Inflammation;MAPK/ERK Pathway;Metabolic Enzyme/Protease;NF-κB
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/astin-b.html
• Solubility: H2O
• Smiles: Cl[C@H](C1)[C@@H](Cl)[C@@](N1C([C@H](CC)NC(C[C@H](C2=CC=CC=C2)N3)=O)=O)([H])C(N[C@H]([C@H](C)O)C(N[C@@H](CO)C3=O)=O)=O
• Molecular Weight: 586.46
• References & Citations: [1]Wang L, et al. Astin B, a cyclic pentapeptide from Aster tataricus, induces apoptosis and autophagy in human hepatic L-02 cells. Chem Biol Interact. 2014 Nov 5;223:1-9.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported