Astin C

• Description:

  Astin C (Asterin) is a cyclopeptide that can be extracted from Aster tataricus. Astin C has anti-inflammatory and anti-cancer activities. Astin C can specifically inhibit the cGAS-STING signaling pathway, block the recruitment of IRF3 to the STING signalosome, and thus inhibit the innate inflammatory response. Astin C can be used in the research of autoimmune diseases and cancers[1][2][3].

• Product Name Alternative:

  Asterin

• UNSPSC:

  12352209

• Target:

  HSV; STING

• Type:

  Peptides

• Related Pathways:

  Anti-infection; Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/astin-c.html

• Purity:

  99.47

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(C[C@H](C1=CC=CC=C1)NC([C@H](CO)NC([C@@H](CC)N2)=O)=O)N[C@@H](CC)C(N3[C@]([C@H](Cl)[C@H](Cl)C3)([H])C2=O)=O

• Molecular Formula:

  C25H33Cl2N5O6

• Molecular Weight:

  570.47

• References & Citations:

  [1]Antoine Vassaux, et al. Astin C Production by the Endophytic Fungus Cyanodermella asteris in Planktonic and Immobilized Culture Conditions. Biotechnol J. 2019 Aug;14 (8) :e1800624. |[2]Li S, et al. The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING. Cell Rep. 2018 Dec 18;25 (12) :3405-3421.e7.|[3]Morita H, et al. Cyclic peptides from higher plants. XXVIII. Antitumor activity and hepatic microsomal biotransformation of cyclic pentapeptides, astins, from Aster tataricus. Chem Pharm Bull (Tokyo) . 1996 May;44 (5) :1026-32.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  [148057-23-2]