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Astin C

CAT: 0804-HY-P1680-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1680-01Size:1 mg
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Description
Astin C (Asterin) is a cyclopeptide that can be extracted from Aster tataricus. Astin C has anti-inflammatory and anti-cancer activities. Astin C can specifically inhibit the cGAS-STING signaling pathway, block the recruitment of IRF3 to the STING signalosome, and thus inhibit the innate inflammatory response. Astin C can be used in the research of autoimmune diseases and cancers[1][2][3].
CAS Number
148057-23-2
Product Name Alternative
Asterin
UNSPSC
12352209
Target
HSV; STING
Type
Peptides
Related Pathways
Anti-infection; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/astin-c.html
Purity
99.47
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C[C@H](C1=CC=CC=C1)NC([C@H](CO)NC([C@@H](CC)N2)=O)=O)N[C@@H](CC)C(N3[C@]([C@H](Cl)[C@H](Cl)C3)([H])C2=O)=O
Molecular Formula
C25H33Cl2N5O6
Molecular Weight
570.47
References & Citations
[1]Antoine Vassaux, et al. Astin C Production by the Endophytic Fungus Cyanodermella asteris in Planktonic and Immobilized Culture Conditions. Biotechnol J. 2019 Aug;14 (8) :e1800624. |[2]Li S, et al. The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING. Cell Rep. 2018 Dec 18;25 (12) :3405-3421.e7.|[3]Morita H, et al. Cyclic peptides from higher plants. XXVIII. Antitumor activity and hepatic microsomal biotransformation of cyclic pentapeptides, astins, from Aster tataricus. Chem Pharm Bull (Tokyo) . 1996 May;44 (5) :1026-32.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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