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Toremifene (citrate) (Standard)

CAT: 0804-HY-B0005R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0005R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Toremifene (citrate) (Standard) is the analytical standard of Toremifene (citrate) . This product is intended for research and analytical applications. Toremifene citrate (Z-Toremifene citrate) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 µM and 2.6 µM, respectively[1][2].
CAS Number
89778-27-8
Product Name Alternative
Z-Toremifene (citrate) (Standard) ; NK 622 (Standard) ; FC-1157a (Standard)
UNSPSC
12352005
Target
Apoptosis; Estrogen Receptor/ERR; Reference Standards
Type
Reference Standards
Related Pathways
Apoptosis; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/toremifene-citrate-standard.html
Smiles
ClCC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C)C)C=C2)\C3=CC=CC=C3.O=C(CC(C(O)=O)(O)CC(O)=O)O
Molecular Formula
C32H36ClNO8
Molecular Weight
598.08
References & Citations
[1]Matthew R Smith, Selective Estrogen Receptor Modulators to Prevent Treatment-Related Osteoporosis.Rev Urol. 2005; 7 (Suppl 3) : S30-S35.|[2]Gauri J Sabnis, Luciana Macedo, Olga Goloubeva, Toremifene - Atamestane; Alone or In Combination: Predictions from the Preclinical Intratumoral Aromatase Model. J Steroid Biochem Mol Biol. 2008 January; 108 (1-2) : 1-7.|[3]Taneja SS, Morton R, Barnette G, Prostate cancer diagnosis among men with isolated high-grade intraepithelial neoplasia enrolled onto a 3-year prospective phase III clinical trial of oral toremifene. J Clin Oncol. 2013 Feb 10;31 (5) :523-9.|[4]Laura Cooper, et al. Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. J Med Chem. 2020 Sep 4.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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