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Mosapride (citrate) (Standard)

CAT: 0804-HY-B0189AR-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0189AR-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mosapride (citrate) (Standard) is the analytical standard of Mosapride (citrate) . This product is intended for research and analytical applications. Mosapride citrate is an orally active gastroenterokinetic compound. Mosapride citrate is a 5HT4 agonist. Mosapride citrate is a CYP inducer. Mosapride citrate has a concentration-dependent inhibitory effect on Kv4.3, and its IC50 value is 15.2 μM. Mosapride citrate can be used in the study of gastrointestinal diseases[1][2][3][4][5][6][7].
CAS Number
112885-42-4
UNSPSC
12352100
Target
5-HT Receptor; Cytochrome P450; Potassium Channel; Reference Standards
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Field of Research
Neurological Disease; Cancer
Smiles
O=C(NCC1CN(CC2=CC=C(F)C=C2)CCO1)C3=CC(Cl)=C(N)C=C3OCC.O=C(CC(C(O)=O)(O)CC(O)=O)O
Molecular Formula
C27H33ClFN3O10
Molecular Weight
614.02
References & Citations
[1]Tack J, et al. Systematic review: cardiovascular safety profile of 5-HT (4) agonists developed for gastrointestinal disorders. Aliment Pharmacol Ther. 2012 Apr;35 (7) :745-67.|[2]Curran MP, et al. Mosapride in gastrointestinal disorders. Drugs. 2008;68 (7) :981-91.|[3]Kim HS, et al. The effect of mosapride citrate on proximal and distal colonic motor function in the guinea-pig in vitro. Neurogastroenterol Motil. 2008 Feb;20 (2) :169-76.|[4]Kim YH, et al. Measurement of Human Cytochrome P450 Enzyme Induction Based on Mesalazine and Mosapride Citrate Treatments Using a Luminescent Assay. Biomol Ther (Seoul) . 2015 Sep;23 (5) :486-92.|[5]Uchida M, et al. Dual role of mosapride citrate hydrate on the gastric emptying evaluated by the breath test in conscious rats. J Pharmacol Sci. 2013;121 (4) :282-7.|[6]Fujisawa M, et al. The 5-HT4 receptor agonist mosapride attenuates NSAID-induced gastric mucosal damage. J Gastroenterol. 2010 Feb;45 (2) :179-86.|[7]Sung KW, et al. Effect of mosapride on Kv4.3 potassium channels expressed in CHO cells. Naunyn Schmiedebergs Arch Pharmacol. 2013 Oct;386 (10) :905-16.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

Mosapride citrate
CAS Number112885-42-4
PubChem CID119583
IUPAC Name4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide;2-hydroxypropane-1,2,3-tricarboxylic acid
Molecular FormulaC27H33ClFN3O10
Molecular Weight614.0
Topological Polar Surface Area209
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count13
Rotatable Bond Count12
Heavy Atom Count42
Formal Charge0
Complexity749
SMILES
CCOC1=CC(=C(C=C1C(=O)NCC2CN(CCO2)CC3=CC=C(C=C3)F)Cl)N.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
InChI
InChI=1S/C21H25ClFN3O3.C6H8O7/c1-2-28-20-10-19(24)18(22)9-17(20)21(27)25-11-16-13-26(7-8-29-16)12-14-3-5-15(23)6-4-14;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-6,9-10,16H,2,7-8,11-13,24H2,1H3,(H,25,27);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InChIKey
HUZTYZBFZKRPFG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Mosapride citrate
CAS: 112885-42-4
CID: 119583
Formula: C27H33ClFN3O10
MW: 614.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight614.0
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count13
Rotatable Bond Count12
Exact Mass613.1838501
Monoisotopic Mass613.1838501
Topological Polar Surface Area209 Ų
Heavy Atom Count42
Formal Charge0
Complexity749
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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