Monascin (Standard)

Monascin (Standard) is the analytical standard of Monascin. This product is intended for research and analytical applications. Monascin is a kind of azaphilonoid pigments extracted from Monascus pilosus-fermented rice (red-mold rice) . Monascin also exhibits anti-tumor-initiating activity and anti-inflammatory activity with oral administration. Monascin inhibits the activation of NOR 1 (an NO donor) . Monascin is a Nrf2 activator and PPARγ agonist[1][2].

21516-68-7

12352005

Keap1-Nrf2; PPAR; Reference Standards

Reference compound

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; NF-κB; Others; Vitamin D Related/Nuclear Receptor

Cancer; Inflammation/Immunology

https://www.medchemexpress.com/monascin-standard.html

O=C([C@@H]1C(CCCCC)=O)O[C@]2(C)[C@]1([H])CC(C=C(/C=C/C)OC3)=C3C2=O

C21H26O5

358.43

[1]Akihisa T, et al. Anti-tumor-initiating effects of monascin, an azaphilonoid pigment from the extract of Monascus pilosus fermented rice (red-mold rice) . Chem Biodivers. 2005 Oct;2 (10) :1305-9.|[2]Lee CL, et al. Monascus fermentation of dioscorea for increasing the production of cholesterol-lowering agent--monacolin K and antiinflammation agent--monascin. Appl Microbiol Biotechnol. 2006 Oct;72 (6) :1254-62.|[3]Shi YX, Chen WS. Monascin ameliorate inflammation in the lipopolysaccharide-induced BV-2 microglial cells via suppressing the NF-κB/p65 pathway. Iran J Basic Med Sci. 2020;23 (4) :461-468. |[4]Hsu WH, et al. A novel natural Nrf2 activator with PPARγ-agonist (monascin) attenuates the toxicity of methylglyoxal and hyperglycemia. Toxicol Appl Pharmacol. 2013 Nov 1;272 (3) :842-51. |[5]Akihisa T, et al. Anti-tumor-initiating effects of monascin, an azaphilonoid pigment from the extract of Monascus pilosus fermented rice (red-mold rice) . Chem Biodivers. 2005 Oct;2 (10) :1305-9.|[6]Lee CL, et al. Monascus fermentation of dioscorea for increasing the production of cholesterol-lowering agent--monacolin K and antiinflammation agent--monascin. Appl Microbiol Biotechnol. 2006 Oct;72 (6) :1254-62.|[7]Shi YX, Chen WS. Monascin ameliorate inflammation in the lipopolysaccharide-induced BV-2 microglial cells via suppressing the NF-κB/p65 pathway. Iran J Basic Med Sci. 2020;23 (4) :461-468. |[8]Hsu WH, et al. A novel natural Nrf2 activator with PPARγ-agonist (monascin) attenuates the toxicity of methylglyoxal and hyperglycemia. Toxicol Appl Pharmacol. 2013 Nov 1;272 (3) :842-51.

Room temperature